These included NAMPT, IL6, IL1B, and NLRP3, which are typically activated when the body is under physical or metabolic stress. Another gene, SGK1, which influences how the kidneys retain sodium (salt), also became less active.
These findings align with earlier studies showing that daily orange juice consumption can lower blood pressure, particularly in young adults.
More Than Just Sugar in a Glass
This is significant because it helps explain why orange juice has repeatedly been linked to better heart health. Rather than simply raising blood sugar levels, orange juice appears to trigger subtle changes in the body’s regulatory systems—reducing inflammation and helping blood vessels relax.
Much of this effect is attributed to hesperidin, a citrus flavonoid with antioxidant and anti-inflammatory properties. Hesperidin has been shown to influence pathways related to blood pressure, cholesterol balance, and glucose metabolism.
Individual Responses May Vary
Interestingly, the effects of orange juice appear to differ depending on body composition. People carrying more body weight showed stronger changes in genes involved in fat metabolism, while leaner individuals experienced more pronounced reductions in inflammation-related gene activity.
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